I came to this conclusion because I notice a difference in my style of play playing each way 'round. I'm left-handed but am actually used to playing right-handed, unfortunately,because that's how arcade machines are set up (though as a kid I played left-handed...good ole Atari joystick!). But I find that when I play that way around (right-handed) I am forced to rely on intuition, and it's harder work to THINK about what I'm doing... The other way around I can be more analytical and can time things much more precisely. Bosses are easier! If anyone's seen a recording of mine you might notice my "body language" is more panicky than it needs to be, perhaps. I think it's because I'm not judging things discretely but relying on impressions (or intuition).
I've only tried DonPachi a few times but I've found that I'm much better playing the other way round - the way I'm NOT used to (left-handed) - which is the way I'm supposed to play. It's simply impossible to "feel" my way around a game like that intuitively - there's just so much going on that it swamps the senses.
I mean to get used to playing the other way around, but I've only got a keyboard which hampers things anyway. Maybe I'll start submitting the other way around if I can be bothered sitting down and relearning a game with that approach...
The recording will demonstrate what the heck I'm talking about.

-Graham (GSH@TeamBee)